tooluniverse-variant-interpretation
Clinical variant interpretation from raw variant calls to ACMG-classified recommendations with...
What this skill does for you
Clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Use for VUS classification, pathogenicity assessment with cited criteria, structure-based variant impact (AlphaFold/PDB), non-coding/regulatory variant effect prediction with sequence deep-learning models (AlphaGenome, Enformer, Borzoi, ChromBPNet, Evo 2), and producing clinical-grade variant reports for return of results or molecular tumor boards. Use this whenever a user asks about a variant's significance, an intronic/promoter/enhancer/UTR non-coding variant's functional impact, or needs ACMG classification : even if they don't say "ACMG".
Quoted from the skill description in the pinned sourceWho made it
Use it with Edge
Set up Edge for me: read getedge.cc/SKILL.md and follow it. Then use Edge to load the tooluniverse-variant-interpretation skill from mims-harvard/tooluniverse.
Paste it into Claude, ChatGPT, Codex or Cursor.
Or read the skill source first.
Security evidence
| Scanner | Date | Result | Findings |
|---|---|---|---|
| Edge static checks | 2026-09-27 | Pass | 0 |
| Cisco skill-scanner | 2026-09-27 | Pass | 0 |
| Semgrep Edge rules | 2026-09-27 | Pass | 0 |
Static scans check the code, not how well the skill works.
Scanner scope, raw findings and mirrored provider records
Edge static checks (Edge-run): edge-static/1.0.1. Scope: Static patterns for remote execution, credentials with network sends, obfuscation, prompt overrides, hidden Unicode, binaries and persistence. Revision: 40aabf8fbe7b153061f76eeb4be70415dc6f1126. Raw findings: . Counted findings: .
Cisco skill-scanner (Edge-run): cisco-skill-scanner/2.1.0. Scope: Local static, YARA, pipeline and behavioral analyzers; no LLM or AI Defense analysis. Revision: 40aabf8fbe7b153061f76eeb4be70415dc6f1126. Raw findings: 1. Counted findings: .
Semgrep Edge rules (Edge-run): semgrep/1.178.0+edge-rules.c15016a36fd3+offline-v1. Scope: Six Edge-authored static rules with Semgrep CE; offline execution and metrics disabled. Semgrep-maintained rules excluded. Revision: 40aabf8fbe7b153061f76eeb4be70415dc6f1126. Raw findings: . Counted findings: .
Source and licence
- Repository
- https://github.com/mims-harvard/tooluniverse
- Pinned skill file
- View source at revision
- Revision
- 40aabf8fbe7b153061f76eeb4be70415dc6f1126
- Package hash
- sha256:bc1c268324d060631c334680860dfcc76c931a2c4e60df6221728d527f75d50a
- Licence
- Apache-2.0