tooluniverse-polygenic-risk-score

Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics.

What this skill does for you

Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics. Covers PRS construction (clumping/thresholding, PRS-CS), validation in independent cohorts, ancestry-aware adjustment, and clinical interpretation (population-relative risk, not absolute prediction). Use for PRS-based risk stratification.

Quoted from the skill description in the pinned source

Who made it

Publishermims-harvard

Repositorytooluniverse

Installs340as of Sep 27, 2026

Use it with Edge

Set up Edge for me: read getedge.cc/SKILL.md and follow it. Then use Edge to load the tooluniverse-polygenic-risk-score skill from mims-harvard/tooluniverse.

Paste it into Claude, ChatGPT, Codex or Cursor.

Or read the skill source first.

Security evidence

Security state at 2026-09-30: reviewed. State definitions. This records static evidence for this revision; live load eligibility is checked again.

3 static scans, 0 counted findings. The listed scanners recorded the results shown for this package revision.

Scanner	Date	Result
Edge static checks	2026-09-27	Pass
Cisco skill-scanner	2026-09-27	Pass
Semgrep Edge rules	2026-09-27	Pass

Static scans check the code, not how well the skill works.

Scanner scope, raw findings and mirrored provider records

Edge static checks (Edge-run): edge-static/1.0.1. Scope: Static patterns for remote execution, credentials with network sends, obfuscation, prompt overrides, hidden Unicode, binaries and persistence. Revision: 40aabf8fbe7b153061f76eeb4be70415dc6f1126. Raw findings: . Counted findings: .

Cisco skill-scanner (Edge-run): cisco-skill-scanner/2.1.0. Scope: Local static, YARA, pipeline and behavioral analyzers; no LLM or AI Defense analysis. Revision: 40aabf8fbe7b153061f76eeb4be70415dc6f1126. Raw findings: 1. Counted findings: .

Semgrep Edge rules (Edge-run): semgrep/1.178.0+edge-rules.c15016a36fd3+offline-v1. Scope: Six Edge-authored static rules with Semgrep CE; offline execution and metrics disabled. Semgrep-maintained rules excluded. Revision: 40aabf8fbe7b153061f76eeb4be70415dc6f1126. Raw findings: . Counted findings: .

Source and licence

Repository: https://github.com/mims-harvard/tooluniverse
Pinned skill file: View source at revision
Revision: 40aabf8fbe7b153061f76eeb4be70415dc6f1126
Package hash: sha256:3be124b02f5c6a49608d4c0c832cace4350f6c11af730e110ff9651f6fa260f8
Licence: Apache-2.0